Biomarkers associated with severe hypoglycaemia and death in ACCORD.

ABSTRACT:

Aims and hypothesis

In patients with Type 2 diabetes, intensive glycaemic control is associated with hypoglycaemia and possibly increased mortality. However, no blood biomarkers exist to predict these outcomes. Using participants from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) study, we hypothesized that insulin deficiency and islet autoantibodies in patients with clinically diagnosed Type 2 diabetes would be associated with severe hypoglycaemia and death.

Methods

A nested case-control study design was used. A case (n = 86) was a participant who died with at least one episode of severe hypoglycaemia, defined as hypoglycaemia requiring assistance, at any point during ACCORD follow-up. A control (n = 344) was a participant who did not die and did not have s

SUBMITTER: Chow LS 

PROVIDER: S-EPMC4751070 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature