Caveolae as a target to quench autoinduction of the metastatic phenotype in lung cancer.

ABSTRACT:

Purpose

Mevalonate pathway inhibitors are potentially useful chemotherapeutic agents showing growth inhibition and pro-apoptotic effects in cancer cells. The effects of statins and bisphosphonates on cancer growth are attributed to a reduction in protein isoprenylation. Post-translational modification and activation of GTPase binding Ras superfamily permit the recruitment of these signal proteins to membranes where they mediate the cancer phenotype. Here, the effects of three inhibitors of the mevalonate pathway and one specific inhibitor of sterol regulatory element-binding proteins were studied in both an ER-negative, Ras-inactive breast (MDA-MB-231) and lung adenocarcinoma (CaLu-1) cells in vitro.

Methods

Treated cells were subject to genome-wide gene expression profiling

SUBMITTER: Garnett DJ 

PROVIDER: S-EPMC4751176 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature