DINGO: differential network analysis in genomics.

ABSTRACT:

Motivation

Cancer progression and development are initiated by aberrations in various molecular networks through coordinated changes across multiple genes and pathways. It is important to understand how these networks change under different stress conditions and/or patient-specific groups to infer differential patterns of activation and inhibition. Existing methods are limited to correlation networks that are independently estimated from separate group-specific data and without due consideration of relationships that are conserved across multiple groups.

Method

We propose a pathway-based differential network analysis in genomics (DINGO) model for estimating group-specific networks and making inference on the differential networks. DINGO jointly estimates the group-specific c

SUBMITTER: Ha MJ 

PROVIDER: S-EPMC4751246 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature