Impaired fasting glucose, single-nucleotide polymorphisms, and risk for colorectal cancer in Koreans.

ABSTRACT:

Objectives

Numerous studies have demonstrated that fasting serum glucose (FSG) levels and certain single-nucleotide polymorphisms (SNPs) are related to an increased risk of colorectal cancer (CRC); however, their combined effects are still unclear.

Methods

Of a total of 144,527 men and women free of cancer at baseline, 317 developed CRC during 5.3 years of follow-up. A case-cohort study (n=1,691) was used, consisting of participants with a DNA sample available. Three well-known SNPs (rs3802842, rs6983267, rs10795668) were genotyped. Hazard ratios (HR) and 95% confidence intervals (CI) of CRC, colon and rectal cancer were calculated, with the Cox proportional hazard models.

Results

The crude incidence rates per 100,000 person-years were 41.1 overall, 48.4 for men, and

SUBMITTER: Jung KJ 

PROVIDER: S-EPMC4751348 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature