Genomic sequencing of a dyslexia susceptibility haplotype encompassing ROBO1.

ABSTRACT:

Background

The DYX5 locus for developmental dyslexia was mapped to chromosome 3 by linkage study of a large Finnish family, and later, roundabout guidance receptor 1 (ROBO1) was implicated as a candidate gene at DYX5 with suppressed expression from the segregating rare haplotype. A functional magnetoencephalographic study of several family members revealed abnormal auditory processing of interaural interaction, supporting a defect in midline crossing of auditory pathways. In the current study, we have characterized genetic variation in the broad ROBO1 gene region in the DYX5-linked family, aiming to identify variants that would increase our understanding of the altered expression of ROBO1.

Methods

We have used a whole genome sequencing strategy on a pooled sample of 19 indiv

SUBMITTER: Massinen S 

PROVIDER: S-EPMC4751651 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature