Sarcosine Catabolism in Pseudomonas aeruginosa Is Transcriptionally Regulated by SouR.

ABSTRACT:

Unlabelled

Sarcosine (N-methylglycine) is present in many environments inhabited by pseudomonads and is likely most often encountered as an intermediate in the metabolism of choline, carnitine, creatine, and glyphosate. While the enzymology of sarcosine metabolism has been relatively well studied in bacteria, the regulatory mechanisms governing catabolism have remained largely unknown. We previously determined that the sarcosine-catabolic (sox) operon of Pseudomonas aeruginosa is induced by the AraC family regulator GbdR in response to glycine betaine and dimethylglycine. However, induction of these genes was still observed in response to sarcosine in a gbdR deletion mutant, indicating that an independent sarcosine-responsive transcription factor also acted at this locus. Our goal

SUBMITTER: Willsey GG 

PROVIDER: S-EPMC4751790 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature