HexR Controls Glucose-Responsive Genes and Central Carbon Metabolism in Neisseria meningitidis.

ABSTRACT:

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Neisseria meningitidis, an exclusively human pathogen and the leading cause of bacterial meningitis, must adapt to different host niches during human infection. N. meningitidis can utilize a restricted range of carbon sources, including lactate, glucose, and pyruvate, whose concentrations vary in host niches. Microarray analysis of N. meningitidis grown in a chemically defined medium in the presence or absence of glucose allowed us to identify genes regulated by carbon source availability. Most such genes are implicated in energy metabolism and transport, and some are implicated in virulence. In particular, genes involved in glucose catabolism were upregulated, whereas genes involved in the tricarboxylic acid cycle were downregulated. Several genes encoding surface-expos

SUBMITTER: Antunes A 

PROVIDER: S-EPMC4751820 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature