Secreted Acb1 Contributes to the Yeast-to-Hypha Transition in Cryptococcus neoformans.

ABSTRACT: Adaptation to stress by eukaryotic pathogens is often accompanied by a transition in cellular morphology. The human fungal pathogen Cryptococcus neoformans is known to switch between the yeast and the filamentous form in response to amoebic predation or during mating. As in the classic dimorphic fungal pathogens, the morphotype is associated with the ability of cryptococci to infect various hosts. Many cryptococcal factors and environmental stimuli, including pheromones (small peptides) and nutrient limitation, are known to induce the yeast-to-hypha transition. We recently discovered that secreted matricellular proteins could also act as intercellular signals to promote the yeast-to-hypha transition. Here we show that the secreted acyl coenzyme A (acyl-CoA)-binding protein Acb1 plays an im

SUBMITTER: Xu X 

PROVIDER: S-EPMC4751841 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature