Viral immunity. Transkingdom control of viral infection and immunity in the mammalian intestine.

ABSTRACT: Viruses that infect the intestine include major human pathogens (retroviruses, noroviruses, rotaviruses, astroviruses, picornaviruses, adenoviruses, herpesviruses) that constitute a serious public health problem worldwide. These viral pathogens are members of a large, complex viral community inhabiting the intestine termed "the enteric virome." Enteric viruses have intimate functional and genetic relationships with both the host and other microbial constituents that inhabit the intestine, such as the bacterial microbiota, their associated phages, helminthes, and fungi, which together constitute the microbiome. Emerging data indicate that enteric viruses regulate, and are in turn regulated by, these other microbes through a series of processes termed "transkingdom interactions." This repres

SUBMITTER: Pfeiffer JK 

PROVIDER: S-EPMC4751997 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature