Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia.

ABSTRACT:

Background

Preeclampsia is a prevalent hypertensive disorder of pregnancy and a leading cause of maternal and neonatal morbidity and mortality worldwide. This pathogenic condition is speculated to be caused by placental abnormalities that contribute to the maternal syndrome. However, the specific factors and signaling pathways that lead to impaired placentas and maternal disease development remain elusive.

Methods and results

Using 2 independent animal models of preeclampsia (genetically engineered pregnant mice with elevated adenosine exclusively in placentas and a pathogenic autoantibody-induced preeclampsia mouse model), we demonstrated that chronically elevated placental adenosine was sufficient to induce hallmark features of preeclampsia, including hypertension, protein

SUBMITTER: Iriyama T 

PROVIDER: S-EPMC4751998 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature