Mechanisms of Resistance to Aminoglycoside Antibiotics: Overview and Perspectives.

ABSTRACT: Aminoglycoside (AG) antibiotics are used to treat many Gram-negative and some Gram-positive infections and, importantly, multidrug-resistant tuberculosis. Among various bacterial species, resistance to AGs arises through a variety of intrinsic and acquired mechanisms. The bacterial cell wall serves as a natural barrier for small molecules such as AGs and may be further fortified via acquired mutations. Efflux pumps work to expel AGs from bacterial cells, and modifications here too may cause further resistance to AGs. Mutations in the ribosomal target of AGs, while rare, also contribute to resistance. Of growing clinical prominence is resistance caused by ribosome methyltransferases. By far the most widespread mechanism of resistance to AGs is the inactivation of these antibiotics by

SUBMITTER: Garneau-Tsodikova S 

PROVIDER: S-EPMC4752126 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature