Structural and Functional Characterization of a Caenorhabditis elegans Genetic Interaction Network within Pathways.

ABSTRACT: A genetic interaction (GI) is defined when the mutation of one gene modifies the phenotypic expression associated with the mutation of a second gene. Genome-wide efforts to map GIs in yeast revealed structural and functional properties of a GI network. This provided insights into the mechanisms underlying the robustness of yeast to genetic and environmental insults, and also into the link existing between genotype and phenotype. While a significant conservation of GIs and GI network structure has been reported between distant yeast species, such a conservation is not clear between unicellular and multicellular organisms. Structural and functional characterization of a GI network in these latter organisms is consequently of high interest. In this study, we present an in-depth characterizati

SUBMITTER: Boucher B 

PROVIDER: S-EPMC4752231 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature