Combined Immune Therapy for the Treatment of Visceral Leishmaniasis.

ABSTRACT: Chronic disease caused by infections, cancer or autoimmunity can result in profound immune suppression. Immunoregulatory networks are established to prevent tissue damage caused by inflammation. Although these immune checkpoints preserve tissue function, they allow pathogens and tumors to persist, and even expand. Immune checkpoint blockade has recently been successfully employed to treat cancer. This strategy modulates immunoregulatory mechanisms to allow host immune cells to kill or control tumors. However, the utility of this approach for controlling established infections has not been extensively investigated. Here, we examined the potential of modulating glucocorticoid-induced TNF receptor-related protein (GITR) on T cells to improve anti-parasitic immunity in blood and spleen tissue

SUBMITTER: Faleiro RJ 

PROVIDER: S-EPMC4752322 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature