Lipid Droplet Formation, Their Localization and Dynamics during Leishmania major Macrophage Infection.

ABSTRACT: Leishmania, the causative agent of vector-borne diseases, known as leishmaniases, is an obligate intracellular parasite within mammalian hosts. The outcome of infection depends largely on the activation status of macrophages, the first line of mammalian defense and the major target cells for parasite replication. Understanding the strategies developed by the parasite to circumvent macrophage defense mechanisms and to survive within those cells help defining novel therapeutic approaches for leishmaniasis. We previously showed the formation of lipid droplets (LDs) in L. major infected macrophages. Here, we provide novel insights on the origin of the formed LDs by determining their cellular distribution and to what extent these high-energy sources are directed to the proximity of Leishmania p

SUBMITTER: Rabhi S 

PROVIDER: S-EPMC4752496 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature