Niacin therapy and the risk of new-onset diabetes: a meta-analysis of randomised controlled trials.

ABSTRACT:

Objective

Previous studies have suggested that niacin treatment raises glucose levels in patients with diabetes and may increase the risk of developing diabetes. We undertook a meta-analysis of published and unpublished data from randomised trials to confirm whether an association exists between niacin and new-onset diabetes.

Methods

We searched Medline, EMBASE and the Cochrane Central Register of Controlled Trials, from 1975 to 2014, for randomised controlled trials of niacin primarily designed to assess its effects on cardiovascular endpoints and cardiovascular surrogate markers. We included trials with ≥50 non-diabetic participants and average follow-up of ≥24 weeks. Published data were tabulated and unpublished data sought from investigators. We calculated risk ratios (R

SUBMITTER: Goldie C 

PROVIDER: S-EPMC4752613 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature