Feedback control in planarian stem cell systems.

ABSTRACT:

Background

In planarian flatworms, the mechanisms underlying the activity of collectively pluripotent adult stem cells (neoblasts) and their descendants can now be studied from the level of the individual gene to the entire animal. Flatworms maintain startling developmental plasticity and regenerative capacity in response to variable nutrient conditions or injury. We develop a model for cell dynamics in such animals, assuming that fully differentiated cells exert feedback control on neoblast activity.

Results

Our model predicts a number of whole organism level and general cell biological and behaviours, some of which have been empirically observed or inferred in planarians and others that have not. As previously observed empirically we find: 1) a curvilinear relationship bet

SUBMITTER: Mangel M 

PROVIDER: S-EPMC4752765 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature