A novel multimodal optical imaging system for early detection of oral cancer.

ABSTRACT:

Objectives

Several imaging techniques have been advocated as clinical adjuncts to improve identification of suspicious oral lesions. However, these have not yet shown superior sensitivity or specificity over conventional oral examination techniques. We developed a multimodal, multi-scale optical imaging system that combines macroscopic biochemical imaging of fluorescence lifetime imaging with subcellular morphologic imaging of reflectance confocal microscopy for early detection of oral cancer. We tested our system on excised human oral tissues.

Study design

In total, 4 tissue specimens were imaged. These specimens were diagnosed as either clinically normal, oral lichen planus, gingival hyperplasia, or superficially invasive squamous cell carcinoma. The optical and fluorescen

SUBMITTER: Malik BH 

PROVIDER: S-EPMC4752880 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature