Neonatal Cytokine Profiles Associated With Autism Spectrum Disorder.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition that can be reliably diagnosed at age 24 months. Immunological phenomena, including skewed cytokine production, have been observed among children with ASD. Little is known about whether immune dysregulation is present before diagnosis of ASD.

Methods

We examined neonatal blood spots from 214 children with ASD (141 severe, 73 mild/moderate), 62 children with typical development, and 27 children with developmental delay as control subjects who participated in the Childhood Autism Risks from Genetics and the Environment study, a population-based case-control study. Levels of 17 cytokines and chemokines were compared across groups and in relation to developmental and behavioral domains.

Result

SUBMITTER: Krakowiak P 

PROVIDER: S-EPMC4753133 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature