Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1.

ABSTRACT: In this study, we report the case of a patient infected with human immunodeficiency virus (HIV)-1 who developed ataxia and neurocognitive impairment due to viral escape within the central nervous system (CNS) with a multidrug-resistant HIV-1 despite long-term viral suppression in plasma. Antiretroviral therapy optimization with drugs with high CNS penetration led to viral suppression in the CSF, regression of ataxia, and improvement of neurocognitive symptoms.

SUBMITTER: Beguelin C 

PROVIDER: S-EPMC4753349 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature