Method parameters' impact on mortality and variability in mouse stroke experiments: a meta-analysis.

ABSTRACT: Although hundreds of promising substances have been tested in clinical trials, thrombolysis currently remains the only specific pharmacological treatment for ischemic stroke. Poor quality, e.g. low statistical power, in the preclinical studies has been suggested to play an important role in these failures. Therefore, it would be attractive to use animal models optimized to minimize unnecessary mortality and outcome variability, or at least to be able to power studies more exactly by predicting variability and mortality given a certain experimental setup. The possible combinations of methodological parameters are innumerous, and an experimental comparison of them all is therefore not feasible. As an alternative approach, we extracted data from 334 experimental mouse stroke articles and, usi

SUBMITTER: Ingberg E 

PROVIDER: S-EPMC4753409 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature