Correspondence of DNA Methylation Between Blood and Brain Tissue and Its Application to Schizophrenia Research.

ABSTRACT: Given the difficulty of procuring human brain tissue, a key question in molecular psychiatry concerns the extent to which epigenetic signatures measured in more accessible tissues such as blood can serve as a surrogate marker for the brain. Here, we aimed (1) to investigate the blood-brain correspondence of DNA methylation using a within-subject design and (2) to identify changes in DNA methylation of brain-related biological pathways in schizophrenia.We obtained paired blood and temporal lobe biopsy samples simultaneously from 12 epilepsy patients during neurosurgical treatment. Using the Infinium 450K methylation array we calculated similarity of blood and brain DNA methylation for each individual separately. We applied our findings by performing gene set enrichment analyses (GSEA) of pe

SUBMITTER: Walton E 

PROVIDER: S-EPMC4753587 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature