Prospective study of plasma urate and risk of Parkinson disease in men and women.

ABSTRACT:

Objective

To examine whether higher plasma urate concentrations are associated with a lower risk of developing Parkinson disease (PD) and whether there is a sex difference in the potential urate-PD relationship.

Methods

We conducted a nested case-control study based on 90,214 participants of 3 ongoing US cohorts. We identified 388 new PD cases (202 men and 186 women) since blood collection, which were then matched to 1,267 controls. PD cases were confirmed by medical record review. Conditional logistic regression estimated relative risks (RRs) and 95% confidence intervals (95% CIs), after adjustment for age, smoking, caffeine intake, plasma concentrations of cholesterol and ferritin, and other covariates. We also conducted a meta-analysis to combine our study with 3 previous

SUBMITTER: Gao X 

PROVIDER: S-EPMC4753729 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature