Interactive Big Data Resource to Elucidate Human Immune Pathways and Diseases.

ABSTRACT: Many functionally important interactions between genes and proteins involved in immunological diseases and processes are unknown. The exponential growth in public high-throughput data offers an opportunity to expand this knowledge. To unlock human-immunology-relevant insight contained in the global biomedical research effort, including all public high-throughput datasets, we performed immunological-pathway-focused Bayesian integration of a comprehensive, heterogeneous compendium comprising 38,088 genome-scale experiments. The distillation of this knowledge into immunological networks of functional relationships between molecular entities (ImmuNet), and tools to mine this resource, are accessible to the public at http://immunet.princeton.edu. The predictive capacity of ImmuNet, established

SUBMITTER: Gorenshteyn D 

PROVIDER: S-EPMC4753773 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature