Clinical Immunophenotype at Disease Onset in Previously Healthy Patients With Cryptococcal Meningitis.

ABSTRACT: Cryptococcal meningitis (CM) is a global disease with significant morbidity and mortality. Although low peripheral blood cluster of differentiation 4 (CD4) cell counts are found to be related to a high burden of cryptococcus in HIV-infected patients, little is known about possible immune defects in previously healthy patients (PHPs). We performed a retrospective study of 41 CM patients treated from January 2005 to December 2014 who did not have HIV-infection. There were 33 PHPs and 8 not previously healthy patients (non-PHPs). We analyzed clinical test data pertaining to peripheral blood T cells, antibodies, inflammation markers, and cerebral spinal fluid (CSF) completed during the disease onset phase and 5 years following diagnosis. PHPs had significantly higher counts of cluster of diffe

SUBMITTER: Xu L 

PROVIDER: S-EPMC4753916 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature