Maternal Highly Active Antiretroviral Therapy and Child HIV-Free Survival in Malawi, 2004-2009.

ABSTRACT:

Objectives

Highly active antiretroviral therapy (HAART) provision to eligible HIV-infected pregnant and post-partum women is critical for optimizing maternal health. We assessed the impact of maternal HAART on HIV-free survival of breastfed infants in Malawi.

Methods

The post-exposure prophylaxis of infants-Malawi trial (2004-2009) enrolled mothers/infants during labor or immediately post-partum to evaluate 14-week extended infant antiretroviral prophylaxis for preventing HIV transmission through breastfeeding. Mothers meeting national HAART guidelines were referred for therapy. Child HIV-free survival-survival without HIV infection-was compared by maternal HAART status.

Results

Overall, 3022 mother-infant pairs contributed 4214 infant/person-years (PY) at-risk for HI

SUBMITTER: Schwartz SR 

PROVIDER: S-EPMC4754130 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature