Timing effect of intramyocardial hydrogel injection for positively impacting left ventricular remodeling after myocardial infarction.

ABSTRACT: Intramyocardial injection of various injectable hydrogel materials has shown benefit in positively impacting the course of left ventricular (LV) remodeling after myocardial infarction (MI). However, since LV remodeling is a complex, time dependent process, the most efficacious time of hydrogel injection is not clear. In this study, we injected a relatively stiff, thermoresponsive and bioabsorbable hydrogel in rat hearts at 3 different time points - immediately after MI (IM), 3 d post-MI (3D), and 2 w post-MI (2W), corresponding to the beginnings of the necrotic, fibrotic and chronic remodeling phases. The employed left anterior descending coronary artery ligation model showed expected infarction responses including functional loss, inflammation and fibrosis with distinct time dependent pat

SUBMITTER: Yoshizumi T 

PROVIDER: S-EPMC4754148 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature