Resting heart rate and all-cause and cardiovascular mortality in the general population: a meta-analysis.

ABSTRACT:

Background

Data on resting heart rate and risk of all-cause and cardiovascular mortality are inconsistent; the magnitude of associations between resting heart rate and risk of all-cause and cardiovascular mortality varies across studies. We performed a meta-analysis of prospective cohort studies to quantitatively evaluate the associations in the general population.

Methods

We searched PubMed, Embase and MEDLINE from inception to Jan. 1, 2015. We used a random-effects model to combine study-specific relative risks and 95% confidence intervals (CIs). We used restricted cubic spline functions to assess the dose-response relation.

Results

A total of 46 studies were included in the meta-analysis, involving 1 246 203 patients and 78 349 deaths for all-cause mortality, and 8

SUBMITTER: Zhang D 

PROVIDER: S-EPMC4754196 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature