Survival after resection of perihilar cholangiocarcinoma-development and external validation of a prognostic nomogram.

ABSTRACT:

Background

The objective of this study was to derive and validate a prognostic nomogram to predict disease-specific survival (DSS) after a curative intent resection of perihilar cholangiocarcinoma (PHC).

Patients and methods

A nomogram was developed from 173 patients treated at Memorial Sloan Kettering Cancer Center (MSKCC), New York, USA. The nomogram was externally validated in 133 patients treated at the Academic Medical Center (AMC), Amsterdam, The Netherlands. Prognostic accuracy was assessed with concordance estimates and calibration, and compared with the American Joint Committee on Cancer (AJCC) staging system. The nomogram will be available as web-based calculator at mskcc.org/nomograms.

Results

For all 306 patients, the median overall survival (OS) was 40 mo

SUBMITTER: Groot Koerkamp B 

PROVIDER: S-EPMC4754626 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature