Theta synchronization between medial prefrontal cortex and cerebellum is associated with adaptive performance of associative learning behavior.

ABSTRACT: Associative learning is thought to require coordinated activities among distributed brain regions. For example, to direct behavior appropriately, the medial prefrontal cortex (mPFC) must encode and maintain sensory information and then interact with the cerebellum during trace eyeblink conditioning (TEBC), a commonly-used associative learning model. However, the mechanisms by which these two distant areas interact remain elusive. By simultaneously recording local field potential (LFP) signals from the mPFC and the cerebellum in guinea pigs undergoing TEBC, we found that theta-frequency (5.0-12.0 Hz) oscillations in the mPFC and the cerebellum became strongly synchronized following presentation of auditory conditioned stimulus. Intriguingly, the conditioned eyeblink response (CR) with adapt

SUBMITTER: Chen H 

PROVIDER: S-EPMC4754690 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature