Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms.

ABSTRACT: Abnormal reward-related responses in the nucleus accumbens (NAcc) have been reported for major depressive disorder (MDD) patients. However, variability exists in the reported results, which could be due to heterogeneity in neuropathology of depression. To parse the heterogeneity of MDD we investigated variation of NAcc responses to gain and loss anticipations using fMRI. We found NAcc responses to monetary gain and loss were significantly variable across subjects in both MDD and healthy control (HC) groups. The variations were seen as a hyperactive response subtype that showed elevated activation to the anticipation of both gain and loss, an intermediate response with greater activation to gain than loss, and a suppressed-activity with reduced activation to both gain and loss compared to a

SUBMITTER: Misaki M 

PROVIDER: S-EPMC4754797 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature