The Klotho gene G-395A polymorphism and metabolic syndrome in very elderly people.

ABSTRACT:

Background

To investigate the possible association of the Klotho G-395A polymorphism and metabolic syndrome (MetS) among a population of Chinese nonagenarians and centenarians.

Methods

Subjects were from the Project of Longevity and Aging in Dujiangyan (PLAD). The genotyping of G-395A (rs1207568) in the promoter region of the Klotho gene was performed using the TaqMan allelic discrimination assay. MetS was diagnosed according to the International Diabetes Federation criteria.

Results

We included 695 subjects aged 93.5 ± 3.2 years. G and A allele frequencies were 0.852 and 0.148, respectively. In the whole population, the frequency of MetS was 10.8% and 5.9% in the GG and GA + AA genotype group, respectively (p = 0.004). The -395A allele carriers had significantly lowe

SUBMITTER: Luo L 

PROVIDER: S-EPMC4754834 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature