MiR-193b promotes autophagy and non-apoptotic cell death in oesophageal cancer cells.

ABSTRACT:

Background

Successful treatment of oesophageal cancer is hampered by recurrent drug resistant disease. We have previously demonstrated the importance of apoptosis and autophagy for the recovery of oesophageal cancer cells following drug treatment. When apoptosis (with autophagy) is induced, these cells are chemosensitive and will not recover following chemotherapy treatment. In contrast, when cancer cells exhibit only autophagy and limited Type II cell death, they are chemoresistant and recover following drug withdrawal.

Methods

MicroRNA (miRNA) expression profiling of an oesophageal cancer cell line panel was used to identify miRNAs that were important in the regulation of apoptosis and autophagy. The effects of miRNA overexpression on cell death mechanisms and recovery wer

SUBMITTER: Nyhan MJ 

PROVIDER: S-EPMC4754993 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature