Ontology highlight
ABSTRACT:
SUBMITTER: Choi SJ
PROVIDER: S-EPMC4755110 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
The EMBO journal 20160108 4
RIG-I is a key cytosolic sensor that detects RNA viruses through its C-terminal region and activates the production of antiviral interferons (IFNs) and proinflammatory cytokines. While posttranslational modification has been demonstrated to regulate RIG-I signaling activity, its significance for the sensing of viral RNAs remains unclear. Here, we first show that the RIG-I C-terminal region undergoes deacetylation to regulate its viral RNA-sensing activity and that the HDAC6-mediated deacetylatio ...[more]