Comparing Genomic Profiles of Women With and Without Fibromyalgia.

ABSTRACT:

Background

Fibromyalgia syndrome (FMS), a chronic musculoskeletal condition characterized by diffuse pain, fatigue, sleep impairment, and cognitive dysfunction, is associated with significant functional disability. Its underlying biological mechanisms are unknown. This study investigated differentially expressed genes between women with FMS and healthy volunteers.

Methods

Women who met the 1990 or 2010 American College of Rheumatology fibromyalgia criteria were compared to age- and race-matched pain-free healthy women. Peripheral blood samples were collected, and a full genome microarray gene expression analysis was performed. One-way analysis of variance was used to identify differentially expressed genes using the filtering criterion of 1% false discovery rate. Analysis of

SUBMITTER: Lukkahatai N 

PROVIDER: S-EPMC4755339 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature