Systemic inflammation and lung function: A longitudinal analysis.

ABSTRACT:

Background

Systemic inflammation is associated with impaired lung function in healthy adults as well as in patients with lung disease. The mechanism for this association is unknown and it is unclear if systemic inflammation leads to impaired lung function or if poor lung function leads to inflammation. We explored the temporal associations between blood C-reactive protein (CRP), fibrinogen, and white blood cells, and lung function in young adults.

Methods

Spirometry, plethysmography, and diffusion capacity were measured in a population-based cohort at ages 32 and 38 years. High-sensitivity CRP, fibrinogen, and white blood cells were measured at the same ages.

Results

Higher levels of CRP and, to a lesser extent, fibrinogen were associated with lower lung volumes in cr

SUBMITTER: Hancox RJ 

PROVIDER: S-EPMC4755486 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature