Amphiphilic macromolecule nanoassemblies suppress smooth muscle cell proliferation and platelet adhesion.

ABSTRACT: While the development of second- and third-generation drug-eluting stents (DES) have significantly improved patient outcomes by reducing smooth muscle cell (SMC) proliferation, DES have also been associated with an increased risk of late-stent thrombosis due to delayed re-endothelialization and hypersensitivity reactions from the drug-polymer coating. Furthermore, DES anti-proliferative agents do not counteract the upstream oxidative stress that triggers the SMC proliferation cascade. In this study, we investigate biocompatible amphiphilic macromolecules (AMs) that address high oxidative lipoprotein microenvironments by competitively binding oxidized lipid receptors and suppressing SMC proliferation with minimal cytotoxicity. To determine the influence of nanoscale assembly on proliferatio

SUBMITTER: Chan JW 

PROVIDER: S-EPMC4755799 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature