Identification of family determining residues in Jumonji-C lysine demethylases: A sequence-based, family wide classification.

ABSTRACT: Histone post-translational modifications play a critical role in the regulation of gene expression. Methylation of lysines at N-terminal tails of histones has been shown to be involved in such regulation. While this modification was long considered to be irreversible, two different classes of enzymes capable of carrying out the demethylation of histone lysines were recently identified: the oxidases, such as LSD1, and the oxygenases (JmjC-containing). Here, a family-wide analysis of the second of these classes is proposed, with over 300 proteins studied at the sequence level. We show that a correlated evolution analysis yields some position/residue pairs which are critical at comparing JmjC sequences and enables the classification of JmjC domains into five families. A few positions appear m

SUBMITTER: Slama P 

PROVIDER: S-EPMC4755873 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature