Intra-Articular Therapies in the Treatment of Hand Osteoarthritis: A Systematic Literature Review.

ABSTRACT:

Background

Local treatments to alleviate symptoms in hand osteoarthritis (OA) are preferred, especially in elderly patients with comorbidities. Therefore, we have summarized the benefits and harms of intra-articular (IA) therapies.

Methods

We conducted a systematic literature review until May 2015, including all controlled trials investigating efficacy or safety of any IA therapy in carpometacarpal (CMC) and interphalangeal (IP) OA compared with placebo or other treatments. Two authors independently selected trials and assessed risk of bias using the Cochrane tool. The main efficacy outcome was pain. We performed meta-analysis where appropriate.

Results

A total of 13 trials (864 patients) studying CMC (n = 11) and IP OA (n = 2) were included, comparing corticosteroids

SUBMITTER: Kroon FP 

PROVIDER: S-EPMC4756050 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature