Taurine Transporter Gene Expression in Mononuclear Blood Cells of Type 1 Diabetes Patients.

ABSTRACT:

Background

Taurine transporter gene expression (RNA-TauT) has a role in retinal cell function and is modulated in vitro and in vivo by hyperglycemia and/or oxidative stress. This study was aimed at testing whether RNA-TauT gene expression is modified in blood mononuclear peripheral cells (MPCs) of type 1 diabetic patients, is related to plasma markers of oxidative stress or endothelial dysfunction, or, finally, is related to presence of retinopathy.

Methods

RNA-TauT was measured in MPCs by real-time PCR-analysis in 35 type 1 diabetic patients and in 33 age- and sex-matched controls, additionally measuring plasma and cell taurine and markers of oxidative stress and endothelial dysfunction.

Results

RNA-TauT, expressed as 2(-ΔΔCt), was significantly higher in MPCs of typ

SUBMITTER: Napoli Z 

PROVIDER: S-EPMC4756203 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature