Engineering long shelf life multi-layer biologically active surfaces on microfluidic devices for point of care applications.

ABSTRACT: Although materials and engineered surfaces are broadly utilized in creating assays and devices with wide applications in diagnostics, preservation of these immuno-functionalized surfaces on microfluidic devices remains a significant challenge to create reliable repeatable assays that would facilitate patient care in resource-constrained settings at the point-of-care (POC), where reliable electricity and refrigeration are lacking. To address this challenge, we present an innovative approach to stabilize surfaces on-chip with multiple layers of immunochemistry. The functionality of microfluidic devices using the presented method is evaluated at room temperature for up to 6-month shelf life. We integrated the preserved microfluidic devices with a lensless complementary metal oxide semiconduct

SUBMITTER: Asghar W 

PROVIDER: S-EPMC4756328 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature