Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes.

ABSTRACT:

Background

Obesity and type 2 diabetes (T2D) are linked both with host genetics and with environmental factors, including dysbioses of the gut microbiota. However, it is unclear whether these microbial changes precede disease onset. Twin cohorts present a unique genetically-controlled opportunity to study the relationships between lifestyle factors and the microbiome. In particular, we hypothesized that family-independent changes in microbial composition and metabolic function during the sub-clinical state of T2D could be either causal or early biomarkers of progression.

Methods

We collected fecal samples and clinical metadata from 20 monozygotic Korean twins at up to two time points, resulting in 36 stool shotgun metagenomes. While the participants were neither obese nor di

SUBMITTER: Yassour M 

PROVIDER: S-EPMC4756455 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature