Response of knee fibrocartilage to joint destabilization.

ABSTRACT:

Objective

A major challenge to understanding osteoarthritis (OA) pathology is identifying the cellular events that precede the onset of cartilage damage. The objective of this study is to determine the effect of joint destabilization on early changes to fibrocartilage in the joint.

Design/methods

The anterior cruciate ligament was transected in collagen reporter mice (Col1CFP and ColXRFP). Mineralization labels were given every 2 weeks to measure new mineralized cartilage apposition. Novel fluorescent histology of mineralized tissue was used to characterize the changes in fibrocartilage at 2 and 4 weeks post-injury.

Results

Changes in fibrocartilaginous structures of the joint occur as early as 2 weeks after injury and are well developed by 4 weeks. The alterations ar

SUBMITTER: Dyment NA 

PROVIDER: S-EPMC4757847 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature