Discovery of high affinity inhibitors of <i>Leishmania donovani N</i>-myristoyltransferase.

ABSTRACT: N-Myristoyltransferase (NMT) is a potential drug target in Leishmania parasites. Scaffold-hopping from published inhibitors yielded the serendipitous discovery of a chemotype selective for Leishmania donovani NMT; development led to high affinity inhibitors with excellent ligand efficiency. The binding mode was characterised by crystallography and provides a structural rationale for selectivity.

SUBMITTER: Rackham MD 

PROVIDER: S-EPMC4757855 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature