Atypical Sulcal Pattern in Children with Developmental Dyslexia and At-Risk Kindergarteners.

ABSTRACT: Developmental dyslexia (DD) is highly heritable and previous studies observed reduced cortical volume, white matter integrity, and functional alterations in left posterior brain regions in individuals with DD. The primary sulcal pattern has been hypothesized to relate to optimal organization and connections of cortical functional areas. It is determined during prenatal development and may reflect early, genetically influenced, brain development. We characterize the sulcal pattern using graph-based pattern analysis and investigate whether sulcal patterns in parieto-temporal and occipito-temporal regions are atypical in elementary school-age children with DD and pre-readers/beginning readers (preschoolers/kindergarteners) with a familial risk (elementary school-age children: n [males/females

SUBMITTER: Im K 

PROVIDER: S-EPMC4757938 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature