Ontology highlight
ABSTRACT:
SUBMITTER: Ambade A
PROVIDER: S-EPMC4758032 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Ambade Aditya A Satishchandran Abhishek A Szabo Gyongyi G
Scientific reports 20160218
Alcohol-related hepatocellular carcinoma (HCC) develops with advanced alcoholic liver disease and liver fibrosis. Using adult mice, we evaluate the effect of alcoholic steatohepatitis on early hepatobiliary carcinoma after initiation by diethyl-nitrosamine (DEN). Here we show that alcohol-fed DEN-injected mice have higher ALT and liver-to-body weight ratio compared to pair-fed DEN-injected mice. Alcohol feeding results in steatohepatitis indicated by increased pro-inflammatory cytokines and fibr ...[more]