Prognostic role of urinary collecting system invasion in renal cell carcinoma: a systematic review and meta-analysis.

ABSTRACT: The relationship between urinary collecting system invasion (UCSI) and oncological outcomes in renal cell carcinoma (RCC) patients has attracted extensive attention recent years. However, the reports were inconsistent and remain controversial. Thus, we performed a systematic literature search of PubMed, Embase, Web of Science and The Cochrane Library databases to identify relevant studies up to June 2015 and conducted a standard meta-analysis of survival outcomes. 17 studies containing 9012 RCC patients satisfied the inclusion criteria. Pooled HRs for overall survival (OS) and recurrence-free survival (RFS) were 1.45 (95%CI, 1.26-1.66, P < 0.001) and 2.27 (95% CI, 1.54-3.34, P < 0.001), respectively. Further subgroup analysis suggested that UCSI was significant associated with poor cancer-

SUBMITTER: Chen L 

PROVIDER: S-EPMC4758053 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature