Integrative Clinical Sequencing in the Management of Refractory or Relapsed Cancer in Youth.

ABSTRACT:

Importance

Cancer is caused by a diverse array of somatic and germline genomic aberrations. Advances in genomic sequencing technologies have improved the ability to detect these molecular aberrations with greater sensitivity. However, integrating them into clinical management in an individualized manner has proven challenging.

Objective

To evaluate the use of integrative clinical sequencing and genetic counseling in the assessment and treatment of children and young adults with cancer.

Design, setting, and participants

Single-site, observational, consecutive case series (May 2012-October 2014) involving 102 children and young adults (mean age, 10.6 years; median age, 11.5 years, range, 0-22 years) with relapsed, refractory, or rare cancer.

Exposures

Participant

SUBMITTER: Mody RJ 

PROVIDER: S-EPMC4758114 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature