Aggrecan heterogeneity in articular cartilage from patients with osteoarthritis.

ABSTRACT:

Background

Aggrecan degradation is the hallmark of cartilage degeneration in osteoarthritis (OA), though it is unclear whether a common proteolytic process occurs in all individuals.

Methods

Aggrecan degradation in articular cartilage from the knees of 33 individuals with OA, who were undergoing joint replacement surgery, was studied by immunoblotting of tissue extracts.

Results

Matrix metalloproteinases (MMPs) and aggrecanases are the major proteases involved in aggrecan degradation within the cartilage, though the proportion of aggrecan cleavage attributable to MMPs or aggrecanases was variable between individuals. However, aggrecanases were more associated with the increase in aggrecan loss associated with OA than MMPs. While the extent of aggrecan cleavage was hig

SUBMITTER: Mort JS 

PROVIDER: S-EPMC4758135 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature