Assessment of biocompatibility of 3D printed photopolymers using zebrafish embryo toxicity assays.

ABSTRACT: 3D printing has emerged as a rapid and cost-efficient manufacturing technique to enable the fabrication of bespoke, complex prototypes. If the technology is to have a significant impact in biomedical applications, such as drug discovery and molecular diagnostics, the devices produced must be biologically compatible to enable their use with established reference assays and protocols. In this work we demonstrate that we can adapt the Fish Embryo Test (FET) as a new method to quantify the toxicity of 3D printed microfluidic devices. We assessed the biocompatibility of four commercially available 3D printing polymers (VisiJetCrystal EX200, Watershed 11122XC, Fototec SLA 7150 Clear and ABSplus P-430), through the observation of key developmental markers in the developing zebrafish embryos. Resu

SUBMITTER: Macdonald NP 

PROVIDER: S-EPMC4758231 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature