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Expansile crosslinked polymersomes for pH sensitive delivery of doxorubicin.

ABSTRACT: We report a new crosslinked polymersome with pH-responsive swelling properties through acidic hydrolysis of hydrophobic contents from the amphiphilic polymer chains. Its unique stability under physiological conditions and large swelling capability under low pH conditions give this polymersome promising potential for anticancer drug delivery.

SUBMITTER: Liu X 

PROVIDER: S-EPMC4758355 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Expansile crosslinked polymersomes for pH sensitive delivery of doxorubicin.

Liu Xifeng X   Yaszemski Michael J MJ   Lu Lichun L  

Biomaterials science 20160201 2

We report a new crosslinked polymersome with pH-responsive swelling properties through acidic hydrolysis of hydrophobic contents from the amphiphilic polymer chains. Its unique stability under physiological conditions and large swelling capability under low pH conditions give this polymersome promising potential for anticancer drug delivery. ...[more]

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